Pii: S0301-5629(00)00316-1

Spectral estimation of tissue strain has been performed previously by using the centroid shift of the power spectrum or by estimating the variation in the mean scatterer spacing in the spectral domain. The centroid shift method illustrates the robustness of the direct, incoherent strain estimator. In this paper, we present a strain estimator that uses spectral cross-correlation of the preand postcompression power spectrum. The centroid shift estimator estimates strain from the mean center frequency shift, while the spectral cross-correlation estimates the shift over the entire spectrum. Spectral cross-correlation is shown to be more sensitive to small shifts in the power spectrum and, thus, provides better estimation for smaller strains when compared to the spectral centroid shift. Spectral cross-correlation shares all the advantages gained using the spectral centroid shift, in addition to providing accurate and precise strain estimation for small strains. The variance and noise properties of the spectral strain estimators quantified by their respective strain filters are also presented. © 2001 World Federation for Ultrasound in Medicine & Biology.